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Life events and borderline personality features: the influence of gene–environment interaction and gene–environment correlation. 2000 30:41–52.ĭistel MA, Middeldorp CM, Trull TJ, Derom CA, Willemsen G, Boomsma DI. Early sexual abuse and lifetime psychopathology: a co-twin–control study. 2013 122:180.ĭinwiddie S, Heath AC, Dunne MP, Bucholz KK, Madden PA, Slutske WS, et al. Tests of a direct effect of childhood abuse on adult borderline personality disorder traits: a longitudinal discordant twin design. 2009 373:68–81.īornovalova MA, Huibregtse BM, Hicks BM, Keyes M, McGue M, Iacono W. Burden and consequences of child maltreatment in high-income countries. Gilbert R, Widom CS, Browne K, Fergusson D, Webb E, Janson S. In addition, future treatments for mental illness will benefit from taking into consideration the co-occurrence of childhood trauma and genetic loading.Ĭenters for Disease Control. Therefore, inherited genetic risk may partly account for the association of childhood abuse with mental illness. A one-standard-deviation increase in genetic risk for mental illness was associated with a modestly elevated risk of experiencing childhood abuse (OR range: 1.05–1.19). Sensitivity analyses examining potential bias from the differential recall of childhood trauma, parental socioeconomic status, and population stratification were consistent with the main findings. ADHD and MDD genetic risk scores were associated with a higher risk of experiencing each type of childhood abuse, while neuroticism, schizophrenia, BPD, and ASD genetic scores were associated with a higher risk of experiencing physical/emotional abuse and physical assault, but not sexual abuse. Using polygenic risk scores for six psychiatric disorders-attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BPD), major depressive disorder (MDD), neuroticism, and schizophrenia-we tested whether genetic risk for mental illness was associated with increased risk of experiencing three types of childhood abuse: physical/emotional abuse, physical assault, and sexual abuse, in a cohort of white non-Hispanic women ( n = 11,315). Yet, the hypothesis that individuals who have experienced childhood abuse may carry genetic loading for mental illness has never been tested with genetic data. Twin studies suggest that inherited genetic risk for mental illness may account for some of these associations. People who experience childhood abuse are at increased risk of mental illness.